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Glucose Effects on Beta-Cell Growth and Survival Require Activation of Insulin Receptors and Insulin Receptor Substrate 2

Insulin and insulin-like growth factor I (IGF-I) are ubiquitous hormones that regulate growth and metabolism of most mammalian cells, including pancreatic β-cells. In addition to being an insulin secretagogue, glucose regulates proliferation and survival of β-cells. However, it is unclear whether th...

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Bibliografische gegevens
Hoofdauteurs: Assmann, Anke, Ueki, Kohjiro, Winnay, Jonathon N., Kadowaki, Takahashi, Kulkarni, Rohit N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682019/
https://ncbi.nlm.nih.gov/pubmed/19273608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01489-08
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