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Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines

Insulin receptor substrate–1 (IRS-1) is pivotal in mediating the actions of insulin and growth factors in most tissues of the body, but its role in insulin-producing β islet cells is unclear. Freshly isolated islets from IRS-1 knockout mice and SV40-transformed IRS-1–deficient β-cell lines exhibit m...

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Detaylı Bibliyografya
Asıl Yazarlar: Kulkarni, Rohit N., Winnay, Jonathon N., Daniels, Molly, Brüning, Jens C., Flier, Sarah N., Hanahan, Douglas, Kahn, C. Ronald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 1999
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC409887/
https://ncbi.nlm.nih.gov/pubmed/10606633
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