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Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs
Ca(2+) antagonist drugs are widely used in therapy of cardiovascular disorders(1,2). Three chemical classes of drugs bind to three separate, but allosterically interacting, receptor sites on Ca(V)1.2 channels, the most prominent voltage-gated Ca(2+) (Ca(V)) channel type in myocytes in cardiac and va...
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| Pubblicato in: | Nature |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5161592/ https://ncbi.nlm.nih.gov/pubmed/27556947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19102 |
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