PAR1 Scaffolds TGFβRII to Downregulate TGF-β Signaling and Activate ESC Differentiation to Endothelial Cells

We studied the function of the G-protein-coupled receptor PAR1 in mediating the differentiation of mouse embryonic stem cells (mESCs) to endothelial cells (ECs) that are capable of inducing neovascularization. We observed that either deletion or activation of PAR1 suppressed mouse embryonic stem cel...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Gong, Haixia, An, Shejuan, Sassmann, Antonia, Liu, Menglin, Mastej, Victoria, Mittal, Manish, Zhang, Wei, Hong, Zhigang, Offermanns, Stefan, Rehman, Jalees, Malik, Asrar B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161529/
https://ncbi.nlm.nih.gov/pubmed/27866874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.10.006
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