TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs

Transforming growth factor (TGF)-βs are dimeric polypeptides that have vital roles in regulating cell growth and differentiation. They signal by assembling a receptor heterotetramer composed of two TβRI:TβRII heterodimers. To investigate whether the two heterodimers bind and signal autonomously, one...

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Detalhes bibliográficos
Main Authors: Huang, Tao, David, Laurent, Mendoza, Valentín, Yang, Yong, Villarreal, Maria, De, Keya, Sun, LuZhe, Fang, Xiaohong, López-Casillas, Fernando, Wrana, Jeffrey L, Hinck, Andrew P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094126/
https://ncbi.nlm.nih.gov/pubmed/21423151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.54
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