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TβR-II Discriminates the High- and Low-Affinity TGF-β Isoforms via Two Hydrogen-Bonded Ion Pairs
The TGF-β isoforms, TGF-β1, -β2, and -β3, share greater than 70% sequence identity and are almost structurally identical. TGF-β2 differs from the others, however, in that it binds the TGF-β type II receptor (TβR-II) with much lower affinity than either TGF-β1 or -β3. It has been previously shown tha...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801812/ https://ncbi.nlm.nih.gov/pubmed/19161338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8019004 |
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