Mutation of TGFβ-RII eliminates NSAID cancer chemoprevention

Non-steroidal anti-inflammatory drugs (NSAIDs) exhibit anti-neoplastic (chemoprevention) activity for sporadic cancers and the hereditary cancer predisposition Lynch syndrome (LS/HNPCC). However, the mechanism of NSAID tumor suppression has remained enigmatic. Defects in the core mismatch repair (MM...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Martín-López, Juana, Gasparini, Pierluigi, Coombes, Kevin, Croce, Carlo M., Boivin, Gregory P., Fishel, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
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Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849154/
https://ncbi.nlm.nih.gov/pubmed/29560090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23792
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