Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children

OBJECTIVES: To characterize the effects of CYP2B6 polymorphisms, diurnal variation and demographic factors on nevirapine pharmacokinetics in African children. METHODS: Non-linear mixed-effects modelling conducted in NONMEM 7.3 described nevirapine plasma concentration–time data from 414 children age...

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Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Bienczak, Andrzej, Cook, Adrian, Wiesner, Lubbe, Mulenga, Veronica, Kityo, Cissy, Kekitiinwa, Addy, Walker, A. Sarah, Owen, Andrew, Gibb, Diana M., Burger, David, McIlleron, Helen, Denti, Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161049/
https://ncbi.nlm.nih.gov/pubmed/27707991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw388
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