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The pharmacokinetics of nevirapine when given with isoniazid in South African HIV-infected individuals

Isoniazid preventive therapy is recommended in patients on antiretroviral therapy. Isoniazid inhibits CYP3A4, which metabolizes nevirapine. Administration of isoniazid may cause higher nevirapine concentrations and toxicity. We studied the effect of isoniazid on nevirapine concentrations in 21 patie...

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Main Authors: DECLOEDT, Eric H, MWANSA-KAMBAFWILE, Judith, VAN DER WALT, Jan-Stefan, MCILLERON, Helen, DENTI, Paolo, SMITH, Peter, WIESNER, Lubbe, RANGAKA, Molebogeng, WILKINSON, Robert J, MAARTENS, Gary
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176729/
https://ncbi.nlm.nih.gov/pubmed/23407222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5588/ijtld.12.0427
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