Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prostate cancer remains still elusive. Moreover, preclinical evidence of the therapeutic efficacy of NOTCH inhibitor...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Revandkar, Ajinkya, Perciato, Maria Luna, Toso, Alberto, Alajati, Abdullah, Chen, Jingjing, Gerber, Hermeto, Dimitrov, Mitko, Rinaldi, Andrea, Delaleu, Nicolas, Pasquini, Emiliano, D'Antuono, Rocco, Pinton, Sandra, Losa, Marco, Gnetti, Letizia, Arribas, Alberto, Fraering, Patrick, Bertoni, Francesco, Nepveu, Alain, Alimonti, Andrea
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159884/
https://ncbi.nlm.nih.gov/pubmed/27941799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13719
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