Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prostate cancer remains still elusive. Moreover, preclinical evidence of the therapeutic efficacy of NOTCH inhibitor...

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Vydáno v:Nat Commun
Hlavní autoři: Revandkar, Ajinkya, Perciato, Maria Luna, Toso, Alberto, Alajati, Abdullah, Chen, Jingjing, Gerber, Hermeto, Dimitrov, Mitko, Rinaldi, Andrea, Delaleu, Nicolas, Pasquini, Emiliano, D'Antuono, Rocco, Pinton, Sandra, Losa, Marco, Gnetti, Letizia, Arribas, Alberto, Fraering, Patrick, Bertoni, Francesco, Nepveu, Alain, Alimonti, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159884/
https://ncbi.nlm.nih.gov/pubmed/27941799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13719
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