Regular Aspirin Use Associates with Lower Risk of Colorectal Cancers With Low Numbers of Tumor-infiltrating Lymphocytes

BACKGROUND & AIMS: Aspirin use reduces colorectal cancer risk. Aspirin, a nonsteroidal anti-inflammatory drug, inhibits PTGS2 (cyclooxygenase-2); PTGS2 promotes inflammation and suppresses T cell-mediated adaptive immunity. We investigated whether the inverse association of aspirin use with colo...

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Gepubliceerd in:Gastroenterology
Hoofdauteurs: Cao, Yin, Nishihara, Reiko, Qian, Zhi Rong, Song, Mingyang, Mima, Kosuke, Inamura, Kentaro, Nowak, Jonathan A., Drew, David A., Lochhead, Paul, Nosho, Katsuhiko, Morikawa, Teppei, Zhang, Xuehong, Wu, Kana, Wang, Molin, Garrett, Wendy S., Giovannucci, Edward L., Fuchs, Charles S., Chan, Andrew T., Ogino, Shuji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159194/
https://ncbi.nlm.nih.gov/pubmed/27475305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2016.07.030
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