Aspirin Use and Risk of Colorectal Cancer According to BRAF Mutation Status

IMPORTANCE: Aspirin use reduces the risk of colorectal carcinoma. Experimental evidence implicates a role of RAF kinases in upregulation of PTGS2 (cyclooxygenase-2), suggesting that BRAF-mutant colonic cells might be less sensitive to the anti-tumor effects of aspirin than BRAF-wild-type neoplastic...

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Autores principales: Nishihara, Reiko, Lochhead, Paul, Kuchiba, Aya, Jung, Seungyoun, Yamauchi, Mai, Liao, Xiaoyun, Imamura, Yu, Qian, Zhi Rong, Morikawa, Teppei, Wang, Molin, Spiegelman, Donna, Cho, Eunyoung, Giovannucci, Edward, Fuchs, Charles S., Chan, Andrew T., Ogino, Shuji
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743040/
https://ncbi.nlm.nih.gov/pubmed/23800934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2013.6599
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