Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of 15-Hydroxyprostaglandin Dehydrogenase (15-PGDH, HPGD)

Aspirin use reduces the risk of colorectal neoplasia, at least in part, through inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase 2)-related pathways. Hydroxyprostaglandin dehydrogenase 15-(NAD) (15-PGDH, HPGD) is downregulated in colorectal cancers and functions as a metabo...

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Main Authors: Fink, Stephen P., Yamauchi, Mai, Nishihara, Reiko, Jung, Seungyoun, Kuchiba, Aya, Wu, Kana, Cho, Eunyoung, Giovannucci, Edward, Fuchs, Charles S., Ogino, Shuji, Markowitz, Sanford D., Chan, Andrew T.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030641/
https://ncbi.nlm.nih.gov/pubmed/24760190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008481
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