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Aspirin Use and Risk of Colorectal Cancer According to BRAF Mutation Status
IMPORTANCE: Aspirin use reduces the risk of colorectal carcinoma. Experimental evidence implicates a role of RAF kinases in upregulation of PTGS2 (cyclooxygenase-2), suggesting that BRAF-mutant colonic cells might be less sensitive to the anti-tumor effects of aspirin than BRAF-wild-type neoplastic...
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| 主要な著者: | , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3743040/ https://ncbi.nlm.nih.gov/pubmed/23800934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2013.6599 |
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