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Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines

Autophagy, a self-digestive system for cytoplasmic components, is required to maintain the amino acid pool for cellular homeostasis. We previously reported that the macrolide antibiotics azithromycin (AZM) and clarithromycin (CAM) have an inhibitory effect on autophagy flux, and they potently enhanc...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Hirasawa, Kazuhiro, Moriya, Shota, Miyahara, Kana, Kazama, Hiromi, Hirota, Ayako, Takemura, Jun, Abe, Akihisa, Inazu, Masato, Hiramoto, Masaki, Tsukahara, Kiyoaki, Miyazawa, Keisuke
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5158196/
https://ncbi.nlm.nih.gov/pubmed/27977675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164529
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