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Cadmium(II) inhibition of human uracil-DNA glycosylase by catalytic water supplantation
Toxic metals are known to inhibit DNA repair but the underlying mechanisms of inhibition are still not fully understood. DNA repair enzymes such as human uracil-DNA glycosylase (hUNG) perform the initial step in the base excision repair (BER) pathway. In this work, we showed that cadmium [Cd(II)], a...
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| Published in: | Sci Rep |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5156901/ https://ncbi.nlm.nih.gov/pubmed/27974818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39137 |
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