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Specificity and Catalytic Mechanism in Family 5 Uracil DNA Glycosylase

UDGb belongs to family 5 of the uracil DNA glycosylase (UDG) superfamily. Here, we report that family 5 UDGb from Thermus thermophilus HB8 is not only a uracil DNA glycosyase acting on G/U, T/U, C/U, and A/U base pairs, but also a hypoxanthine DNA glycosylase acting on G/I, T/I, and A/I base pairs a...

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Bibliographische Detailangaben
Hauptverfasser: Xia, Bo, Liu, Yinling, Li, Wei, Brice, Allyn R., Dominy, Brian N., Cao, Weiguo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140252/
https://ncbi.nlm.nih.gov/pubmed/24838246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.567354
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