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Correlated Mutation in the Evolution of Catalysis in Uracil DNA Glycosylase Superfamily
Enzymes in Uracil DNA glycosylase (UDG) superfamily are essential for the removal of uracil. Family 4 UDGa is a robust uracil DNA glycosylase that only acts on double-stranded and single-stranded uracil-containing DNA. Based on mutational, kinetic and modeling analyses, a catalytic mechanism involvi...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5387724/ https://ncbi.nlm.nih.gov/pubmed/28397787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45978 |
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