Correlated Mutation in the Evolution of Catalysis in Uracil DNA Glycosylase Superfamily

Enzymes in Uracil DNA glycosylase (UDG) superfamily are essential for the removal of uracil. Family 4 UDGa is a robust uracil DNA glycosylase that only acts on double-stranded and single-stranded uracil-containing DNA. Based on mutational, kinetic and modeling analyses, a catalytic mechanism involvi...

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Foilsithe in:Sci Rep
Main Authors: Xia, Bo, Liu, Yinling, Guevara, Jose, Li, Jing, Jilich, Celeste, Yang, Ye, Wang, Liangjiang, Dominy, Brian N., Cao, Weiguo
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387724/
https://ncbi.nlm.nih.gov/pubmed/28397787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45978
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