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Correlated Mutation in the Evolution of Catalysis in Uracil DNA Glycosylase Superfamily

Enzymes in Uracil DNA glycosylase (UDG) superfamily are essential for the removal of uracil. Family 4 UDGa is a robust uracil DNA glycosylase that only acts on double-stranded and single-stranded uracil-containing DNA. Based on mutational, kinetic and modeling analyses, a catalytic mechanism involvi...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Xia, Bo, Liu, Yinling, Guevara, Jose, Li, Jing, Jilich, Celeste, Yang, Ye, Wang, Liangjiang, Dominy, Brian N., Cao, Weiguo
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387724/
https://ncbi.nlm.nih.gov/pubmed/28397787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45978
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