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Cadmium(II) inhibition of human uracil-DNA glycosylase by catalytic water supplantation
Toxic metals are known to inhibit DNA repair but the underlying mechanisms of inhibition are still not fully understood. DNA repair enzymes such as human uracil-DNA glycosylase (hUNG) perform the initial step in the base excision repair (BER) pathway. In this work, we showed that cadmium [Cd(II)], a...
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| Опубликовано в: : | Sci Rep |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5156901/ https://ncbi.nlm.nih.gov/pubmed/27974818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39137 |
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