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Effect of Regulatory Element DNA Methylation on Tissue-Type Plasminogen Activator Gene Expression

Expression of the tissue-type plasminogen activator gene (t-PA; gene name PLAT) is regulated, in part, by epigenetic mechanisms. We investigated the relationship between PLAT methylation and PLAT expression in five primary human cell types and six transformed cell lines. CpG methylation was analyzed...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Dunoyer-Geindre, Sylvie, Rivier-Cordey, Anne-Sophie, Caetano, Carlos, Fish, Richard J., Kruithof, Egbert K. O.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156355/
https://ncbi.nlm.nih.gov/pubmed/27973546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167588
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