17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

Aging is associated with visceral adiposity, metabolic disorders, and chronic low-grade inflammation. 17α-estradiol (17α-E2), a naturally occurring enantiomer of 17β-estradiol (17β-E2), extends life span in male mice through unresolved mechanisms. We tested whether 17α-E2 could alleviate age-related...

Full description

Saved in:
Bibliographic Details
Published in:J Gerontol A Biol Sci Med Sci
Main Authors: Stout, Michael B., Steyn, Frederik J., Jurczak, Michael J., Camporez, Joao-Paulo G., Zhu, Yi, Hawse, John R., Jurk, Diana, Palmer, Allyson K., Xu, Ming, Pirtskhalava, Tamar, Evans, Glenda L., de Souza Santos, Roberta, Frank, Aaron P., White, Thomas A., Monroe, David G., Singh, Ravinder J., Casaclang-Verzosa, Grace, Miller, Jordan D., Clegg, Deborah J., LeBrasseur, Nathan K., von Zglinicki, Thomas, Shulman, Gerald I., Tchkonia, Tamara, Kirkland, James L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155656/
https://ncbi.nlm.nih.gov/pubmed/26809497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glv309
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items