Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming

Friedreich's ataxia (FRDA) is the most common autosomal recessive ataxia. This severe neurodegenerative disease is caused by an expansion of guanine-adenine-adenine (GAA) repeats located in the first intron of the frataxin (FXN) gene, which represses its transcription. Although transcriptional...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Stem Cells Dev
Egile Nagusiak: Polak, Urszula, Li, Yanjie, Butler, Jill Sergesketter, Napierala, Marek
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Mary Ann Liebert, Inc. 2016
Gaiak:
Original Research Reports
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155629/
https://ncbi.nlm.nih.gov/pubmed/27615158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2016.0147
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