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Stalled DNA replication forks at the endogenous GAA repeats drive repeat expansion in Friedreich's ataxia cells
Friedreich's ataxia (FRDA) is caused by the expansion of GAA repeats located in the Frataxin (FXN) gene. The GAA repeats continue to expand in FRDA patients, aggravating symptoms and contributing to disease progression. The mechanism leading to repeats expansion and decreased FXN transcription...
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| Publicat a: | Cell Rep |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5028224/ https://ncbi.nlm.nih.gov/pubmed/27425605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.075 |
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