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Friedreich's ataxia – a case of aberrant transcription termination?
Reduced expression of the mitochondrial protein Frataxin (FXN) is the underlying cause of Friedreich's ataxia. We propose a model of premature termination of FXN transcription induced by pathogenic expanded GAA repeats that links R-loop structures, antisense transcription, and heterochromatin f...
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| 出版年: | Transcription |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4581357/ https://ncbi.nlm.nih.gov/pubmed/25831023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541264.2015.1026538 |
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