Načítá se...
Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich’s ataxia
Friedreich’s ataxia (FRDA) is caused by biallelic expansion of GAA repeats leading to the transcriptional silencing of the frataxin (FXN) gene. The exact molecular mechanism of inhibition of FXN expression is unclear. Herein, we analyze the effects of hyperexpanded GAA repeats on transcription statu...
Uloženo v:
| Hlavní autoři: | , , |
|---|---|
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2011
|
| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3201871/ https://ncbi.nlm.nih.gov/pubmed/21745819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr542 |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!
|