Long intronic GAA•TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia

Friedreich ataxia (FRDA) is caused by hyperexpansion of GAA•TTC repeats located in the first intron of the FXN gene, which inhibits transcription leading to the deficiency of frataxin. The FXN gene is an excellent target for therapeutic intervention since (i) 98% of patients carry the same type of m...

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Bibliografiset tiedot
Päätekijät: Soragni, E., Herman, D., Dent, S. Y. R., Gottesfeld, J. M., Wells, R. D., Napierala, M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2008
Aiheet:
Gene Regulation, Chromatin and Epigenetics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577344/
https://ncbi.nlm.nih.gov/pubmed/18820300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn604
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