DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA·TTC repeats in Friedreich's ataxia

The DNA abnormality found in 98% of Friedreich's ataxia (FRDA) patients is the unstable hyperexpansion of a GAA·TTC triplet repeat in the first intron of the frataxin gene. Expanded GAA·TTC repeats result in decreased transcription and reduced levels of frataxin protein in affected individuals....

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Burnett, Ryan, Melander, Christian, Puckett, James W., Son, Leslie S., Wells, Robert D., Dervan, Peter B., Gottesfeld, Joel M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2006
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544198/
https://ncbi.nlm.nih.gov/pubmed/16857735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604939103
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items