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Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich’s ataxia
Friedreich’s ataxia (FRDA) is caused by biallelic expansion of GAA repeats leading to the transcriptional silencing of the frataxin (FXN) gene. The exact molecular mechanism of inhibition of FXN expression is unclear. Herein, we analyze the effects of hyperexpanded GAA repeats on transcription statu...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2011
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3201871/ https://ncbi.nlm.nih.gov/pubmed/21745819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr542 |
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