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Non-monotonic dynamics and crosstalk in signaling pathways and their implications for pharmacology
Currently, drug discovery approaches commonly assume a monotonic dose-response relationship. However, the assumption of monotonicity is increasingly being challenged. Here we show that for two simple interacting linear signaling pathways that carry two different signals with different physiological...
Tallennettuna:
| Julkaisussa: | Sci Rep |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5155565/ https://ncbi.nlm.nih.gov/pubmed/26087464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11376 |
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