TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments

The RNA-binding protein TRBP is a central component of the Dicer complex. Despite a decade of biochemical and structural studies, the essential functionality of TRBP in microRNA (miRNA) biogenesis remains unknown. Here we show that TRBP is an integral cofactor for time-efficient Dicer processing in...

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發表在:Nat Commun
Main Authors: Fareh, Mohamed, Yeom, Kyu-Hyeon, Haagsma, Anna C., Chauhan, Sweeny, Heo, Inha, Joo, Chirlmin
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155159/
https://ncbi.nlm.nih.gov/pubmed/27934859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13694
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