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TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments
The RNA-binding protein TRBP is a central component of the Dicer complex. Despite a decade of biochemical and structural studies, the essential functionality of TRBP in microRNA (miRNA) biogenesis remains unknown. Here we show that TRBP is an integral cofactor for time-efficient Dicer processing in...
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| Gepubliceerd in: | Nat Commun |
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| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5155159/ https://ncbi.nlm.nih.gov/pubmed/27934859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13694 |
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