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RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer–TRBP complex

MicroRNAs (miRNAs) mediate translational repression or degradation of their target messenger RNAs by RNA interference (RNAi). The primary transcripts of miRNA genes (pri-miRNAs) are sequentially processed by the nuclear Drosha–DGCR8 complex to approximately 60–70 nucleotide (nt) intermediates (pre-m...

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Detalhes bibliográficos
Main Authors: Kawahara, Yukio, Zinshteyn, Boris, Chendrimada, Thimmaiah P, Shiekhattar, Ramin, Nishikura, Kazuko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978079/
https://ncbi.nlm.nih.gov/pubmed/17599088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401011
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