Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression

In mice, generation of autoreactive CD5(+) B cells occurs as a consequence of BCR signaling induced by (self)-ligand exposure from fetal/neonatal B-1 B cell development. A fraction of these cells self-renew and persist as a minor B1 B cell subset throughout life. Here, we show that transfer of early...

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Библиографические подробности
Опубликовано в: :J Exp Med
Главные авторы: Hayakawa, Kyoko, Formica, Anthony M., Brill-Dashoff, Joni, Shinton, Susan A., Ichikawa, Daiju, Zhou, Yan, Morse, Herbert C., Hardy, Richard R.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2016
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154941/
https://ncbi.nlm.nih.gov/pubmed/27899442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160712
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