NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome

Although B cell development requires expression of the B cell antigen receptor (BCR), it remains unclear whether engagement of self-antigen provides a positive impact for most B cells. Here, we show that BCR engagement by self-ligand during development in vivo results in up-regulation of the Nod-lik...

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Bibliographische Detailangaben
Veröffentlicht in:J Exp Med
Hauptverfasser: Hayakawa, Kyoko, Formica, Anthony M., Zhou, Yan, Ichikawa, Daiju, Asano, Masanao, Li, Yue-Sheng, Shinton, Susan A., Brill-Dashoff, Joni, Núñez, Gabriel, Hardy, Richard R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626402/
https://ncbi.nlm.nih.gov/pubmed/28878001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170497
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