Early Generated B-1–Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma–like Neoplasia in Aged Mice

In mice, fetal/neonatal B-1 cell development generates murine CD5(+) B cells (B1a) with autoreactivity. We analyzed B1a cells at the neonatal stage in a V(H)11/D/J(H) knock-in mouse line (V(H)11t) that generates an autoreactive antiphosphatidylcholine BCR. Our study revealed that antiphosphatidylcho...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Hayakawa, Kyoko, Formica, Anthony M., Nakao, Yuka, Ichikawa, Daiju, Shinton, Susan A., Brill-Dashoff, Joni, Smith, Mitchell R., Morse, Herbert C., Hardy, Richard R.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2018
Assuntos:
Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036230/
https://ncbi.nlm.nih.gov/pubmed/29898964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800400
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