Molecular characterization of the lipid GWAS signal on chromosome 18q11.2 implicates HNF4A-mediated regulation of the TMEM241 gene

OBJECTIVE: We recently identified a locus on chromosome 18q11.2 for high serum triglycerides (TGs) in Mexicans. We hypothesize that the lead GWAS single nucleotide polymorphism (SNP) rs9949617, or its linkage disequilibrium (LD) proxies, regulate one of the 5 genes in the TG-associated region. APPRO...

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Опубликовано в: :Arterioscler Thromb Vasc Biol
Главные авторы: Rodríguez, Alejandra, Gonzalez, Luis, Ko, Arthur, Alvarez, Marcus, Miao, Zong, Bhagat, Yash, Nikkola, Elina, Cruz-Bautista, Ivette, Arellano-Campos, Olimpia, Muñoz-Hernández, Linda L., Ordóñez-Sánchez, Maria-Luisa, Rodriguez-Guillen, Rosario, Mohlke, Karen L., Laakso, Markku, Tusie-Luna, Teresa, Aguilar-Salinas, Carlos A., Pajukanta, Päivi
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154300/
https://ncbi.nlm.nih.gov/pubmed/27199446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307182
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