Molecular characterization of the lipid GWAS signal on chromosome 18q11.2 implicates HNF4A-mediated regulation of the TMEM241 gene

OBJECTIVE: We recently identified a locus on chromosome 18q11.2 for high serum triglycerides (TGs) in Mexicans. We hypothesize that the lead GWAS single nucleotide polymorphism (SNP) rs9949617, or its linkage disequilibrium (LD) proxies, regulate one of the 5 genes in the TG-associated region. APPRO...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Rodríguez, Alejandra, Gonzalez, Luis, Ko, Arthur, Alvarez, Marcus, Miao, Zong, Bhagat, Yash, Nikkola, Elina, Cruz-Bautista, Ivette, Arellano-Campos, Olimpia, Muñoz-Hernández, Linda L., Ordóñez-Sánchez, Maria-Luisa, Rodriguez-Guillen, Rosario, Mohlke, Karen L., Laakso, Markku, Tusie-Luna, Teresa, Aguilar-Salinas, Carlos A., Pajukanta, Päivi
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154300/
https://ncbi.nlm.nih.gov/pubmed/27199446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307182
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados