Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people world-wide. Understanding the genetic and molecular mechanisms that underlie obesity-related phenotypes can help to improve treatment options and drug development. Here we perform promoter Capture Hi–C in hu...

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Udgivet i:Nat Commun
Main Authors: Pan, David Z., Garske, Kristina M., Alvarez, Marcus, Bhagat, Yash V., Boocock, James, Nikkola, Elina, Miao, Zong, Raulerson, Chelsea K., Cantor, Rita M., Civelek, Mete, Glastonbury, Craig A., Small, Kerrin S., Boehnke, Michael, Lusis, Aldons J., Sinsheimer, Janet S., Mohlke, Karen L., Laakso, Markku, Pajukanta, Päivi, Ko, Arthur
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904163/
https://ncbi.nlm.nih.gov/pubmed/29666371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03554-9
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