Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution

Integration of genome-wide association study (GWAS) signals with expression quantitative trait loci (eQTL) studies enables identification of candidate genes. However, evaluating whether nearby signals may share causal variants, termed colocalization, is affected by the presence of allelic heterogene...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Wu, Ying, Broadaway, K Alaine, Raulerson, Chelsea K, Scott, Laura J, Pan, Calvin, Ko, Arthur, He, Aiqing, Tilford, Charles, Fuchsberger, Christian, Locke, Adam E, Stringham, Heather M, Jackson, Anne U, Narisu, Narisu, Kuusisto, Johanna, Pajukanta, Päivi, Collins, Francis S, Boehnke, Michael, Laakso, Markku, Lusis, Aldons J, Civelek, Mete, Mohlke, Karen L
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
General Article One
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202621/
https://ncbi.nlm.nih.gov/pubmed/31691812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz263
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