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PrP(C) Association with Lipid Rafts in the Early Secretory Pathway Stabilizes Its Cellular Conformation
The pathological conversion of cellular prion protein (PrP(C)) into the scrapie prion protein (PrP(Sc)) isoform appears to have a central role in the pathogenesis of transmissible spongiform encephalopathies. However, the identity of the intracellular compartment where this conversion occurs is unkn...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Cell Biology
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC515338/ https://ncbi.nlm.nih.gov/pubmed/15229281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-05-0271 |
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