Conformational Properties of β-PrP

Prion propagation involves a conformational transition of the cellular form of prion protein (PrP(C)) to a disease-specific isomer (PrP(Sc)), shifting from a predominantly α-helical conformation to one dominated by β-sheet structure. This conformational transition is of critical importance in unders...

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Detalhes bibliográficos
Main Authors: Hosszu, Laszlo L. P., Trevitt, Clare R., Jones, Samantha, Batchelor, Mark, Scott, David J., Jackson, Graham S., Collinge, John, Waltho, Jonathan P., Clarke, Anthony R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755922/
https://ncbi.nlm.nih.gov/pubmed/19369250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809173200
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