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PrP(C) Association with Lipid Rafts in the Early Secretory Pathway Stabilizes Its Cellular Conformation

The pathological conversion of cellular prion protein (PrP(C)) into the scrapie prion protein (PrP(Sc)) isoform appears to have a central role in the pathogenesis of transmissible spongiform encephalopathies. However, the identity of the intracellular compartment where this conversion occurs is unkn...

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Autors principals: Sarnataro, Daniela, Campana, Vincenza, Paladino, Simona, Stornaiuolo, Mariano, Nitsch, Lucio, Zurzolo, Chiara
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC515338/
https://ncbi.nlm.nih.gov/pubmed/15229281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-05-0271
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