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p21-Mediated Nuclear Retention of Cyclin B1-Cdk1 in Response to Genotoxic Stress
G2 arrest of cells suffering DNA damage in S phase is crucial to avoid their entry into mitosis, with the concomitant risks of oncogenic transformation. According to the current model, signals elicited by DNA damage prevent mitosis by inhibiting both activation and nuclear import of cyclin B1-Cdk1,...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Cell Biology
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC515331/ https://ncbi.nlm.nih.gov/pubmed/15181148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-12-0871 |
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