Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations

The FLT3 Internal Tandem Duplication (FLT3(ITD)) mutation is common in adult acute myeloid leukemia (AML) but rare in early childhood AML. It is not clear why this difference occurs. Here we show that Flt3(ITD) and cooperating Flt3(ITD)/Runx1 mutations cause hematopoietic stem cell depletion and mye...

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Vydáno v:eLife
Hlavní autoři: Porter, Shaina N, Cluster, Andrew S, Yang, Wei, Busken, Kelsey A, Patel, Riddhi M, Ryoo, Jiyeon, Magee, Jeffrey A
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153248/
https://ncbi.nlm.nih.gov/pubmed/27879203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18882
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