The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Hematopoietic Progenitor Hyperproliferation and Malignant Disease In Vivo

Internal tandem duplications in the fms-like tyrosine kinase receptor (FLT3-ITDs) confer a poor prognosis in acute myeloid leukemia. We hypothesized that increased recruitment of the protein tyrosine phosphatase, Shp2, to FLT3-ITDs contributes to FLT3 ligand (FL)-independent hyperproliferation and S...

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Hlavní autoři: Nabinger, Sarah C., Li, XingJun, Ramdas, Baskar, He, Yantao, Zhang, Xian, Zeng, Lifan, Richine, Briana, Bowling, Joshua D., Fukuda, Seiji, Goenka, Shreevrat, Liu, Ziyue, Feng, Gen-Sheng, Yu, Menggang, Sandusky, George E., Boswell, H. Scott, Zhang, Zhong-Yin, Kapur, Reuben, Chan, Rebecca J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916934/
https://ncbi.nlm.nih.gov/pubmed/23103841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.308
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