Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations

The FLT3 Internal Tandem Duplication (FLT3(ITD)) mutation is common in adult acute myeloid leukemia (AML) but rare in early childhood AML. It is not clear why this difference occurs. Here we show that Flt3(ITD) and cooperating Flt3(ITD)/Runx1 mutations cause hematopoietic stem cell depletion and mye...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Porter, Shaina N, Cluster, Andrew S, Yang, Wei, Busken, Kelsey A, Patel, Riddhi M, Ryoo, Jiyeon, Magee, Jeffrey A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153248/
https://ncbi.nlm.nih.gov/pubmed/27879203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18882
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