FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors

Whether signals mediated via growth factor receptors (GFRs) might influence lineage fate in multipotent progenitors (MPPs) is unclear. We explored this issue in a mouse knockin model of gain-of-function Flt3-ITD mutation because FLT3-ITDs are paradoxically restricted to acute myeloid leukemia even t...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Mead, Adam J., Kharazi, Shabnam, Atkinson, Deborah, Macaulay, Iain, Pecquet, Christian, Loughran, Stephen, Lutteropp, Michael, Woll, Petter, Chowdhury, Onima, Luc, Sidinh, Buza-Vidas, Natalija, Ferry, Helen, Clark, Sally-Ann, Goardon, Nicolas, Vyas, Paresh, Constantinescu, Stefan N., Sitnicka, Ewa, Nerlov, Claus, Jacobsen, Sten Eirik W.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2013
Sujets:
Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701326/
https://ncbi.nlm.nih.gov/pubmed/23727242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.04.031
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires