FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors

Whether signals mediated via growth factor receptors (GFRs) might influence lineage fate in multipotent progenitors (MPPs) is unclear. We explored this issue in a mouse knockin model of gain-of-function Flt3-ITD mutation because FLT3-ITDs are paradoxically restricted to acute myeloid leukemia even t...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Mead, Adam J., Kharazi, Shabnam, Atkinson, Deborah, Macaulay, Iain, Pecquet, Christian, Loughran, Stephen, Lutteropp, Michael, Woll, Petter, Chowdhury, Onima, Luc, Sidinh, Buza-Vidas, Natalija, Ferry, Helen, Clark, Sally-Ann, Goardon, Nicolas, Vyas, Paresh, Constantinescu, Stefan N., Sitnicka, Ewa, Nerlov, Claus, Jacobsen, Sten Eirik W.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2013
Teme:
Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701326/
https://ncbi.nlm.nih.gov/pubmed/23727242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.04.031
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items