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Exploiting temporal collateral sensitivity in tumor clonal evolution
The prevailing approach to addressing secondary drug resistance in cancer focuses on treating the resistance mechanisms at relapse. However, the dynamic nature of clonal evolution, along with potential fitness costs and cost compensations, may present exploitable vulnerabilities; a notion that we te...
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| Publicado no: | Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5152932/ https://ncbi.nlm.nih.gov/pubmed/26924578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.045 |
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